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Cephalosporins are acid stable, but many are poorly absorbed. Because they must be given parenterally, most—including those with high activity—are used only in clinical settings. A few, e. g. , cephalexin, are suitable for oral use. Cephalosporins are penicillinase-resistant, but cephalosporinase-forming organisms do exist.
Upon endothelial contact, the platelet is activated with a resultant change in shape and affinity to fibrinogen. Platelets are linked to each other via fibrinogen bridges: they undergo aggregation. Platelet aggregation increases like an avalanche because, once activated, platelets can activate other platelets. |
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